Concordia Genome Foundry

RESEARCH SPOTLIGHT

Featured Research

Collaborations, preprints, and milestone publications highlighting technologies and workflows developed with Foundry platform support.

RESEARCH FEATURE CHRISTOPHER BRETT LAB

Engineering S. cerevisiae extracellular vesicles using synthetic biology

Preprint

Microscopic 3D rendering of yeast extracellular vesicles engineered with synthetic biology cargo

This preprint explores yeast extracellular vesicles as an engineering platform, using synthetic biology workflows to identify and evaluate candidate scaffolds for cargo loading. The work supports iterative design-build-test-learn development for future health and biotechnology applications.

Yeast as a chassis for extracellular vesicle engineering
Candidate scaffold screening for EV cargo loading
Synthetic biology framework for iterative development

Extracellular vesicles Yeast Synthetic biology Screening Biotechnology

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RESEARCH FEATURE VINCENT MARTIN LAB

Heterologous engineering of receptors using OrthoRep (HERO) for directed evolution of GPCRs in yeast

Preprint

This collaboration used the Foundry’s MAESTRO platform to automate growth-triggered serial passaging for GPCR evolution in yeast. The result is a high-throughput workflow for receptor engineering that combines synthetic biology, automation, and directed evolution.

OrthoRep-based directed evolution in yeast
Automated growth-triggered serial passaging on MAESTRO
Improved signaling for human GPCR targets

Synthetic biology Directed evolution GPCRs Yeast Automation

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3D molecular model and automated liquid handler illustrating OrthoRep HERO directed evolution of GPCRs in yeast

RESEARCH FEATURE VINCENT MARTIN LAB – AGROPUR COLLABORATION

From whey permeate to fumaric acid

Published research

Bioprocess illustration showing Kluyveromyces marxianus converting dairy whey permeate to fumaric acid

This published collaboration explores Kluyveromyces marxianus as a platform for converting lactose-rich dairy permeate into fumaric acid. The work combines host evaluation, genetic variant engineering, and fermentation optimization to demonstrate a viable bioprocess route from dairy side streams to a valuable biochemical.

K. marxianus as a host for whey valorization
Fermentation optimization on lactose-rich dairy permeate
Published route to fumaric acid production

Microbial bioprocessing K. marxianus Whey permeate valorization Fermentation Fumaric acid

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CATALOGUE

Selected Publications

Peer-reviewed articles, review papers, and preprints co-authored by Foundry researchers or enabled by our platform instruments.

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